Garry Ringrose and Iain Henderson are out of Ireland's final match in this year's Six Nations campaign.
The IRFU say that Ringrose is 'doing well' after a head knock during the win against Scotland while Henderson will undergo surgery on a fractured forearm.
Calean Doris' hip complaint and shoulder injuries picked up by Dan Sheehan and Ronan Kelleher will be managed this week.
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Uncapped duo Ross Molony and Tom Stewart have been called up as cover for lock and hooker respectively.