Manchester United head into the international break on the back of one win in their last six Premier League games.
They lost to City 2-nil in the Manchester derby, with the champions moving up to second.
Eric Bailly scored an own goal inside ten minutes, before Bernado Silva's effort on the stroke of half-time sealed the points.
United legend Roy Keane says his old side were completely outplayed
Chelsea can extend their lead at the top of the table with a win at home to Burnley, while Crystal Palace are hosting Wolves and Brentford are taking on Norwich,
In the day's evening kick-off, Brighton are in action against a Newcastle side still seeking their first top flight win of the season.