Republic of Ireland goalkeeper Caomhin Kelleher will start for Liverpool in their game at PSV Eindhoven.
The Premier League leaders are already assured of a top two finish - and have opted to rest a number of their first choice players.
Arsenal have all-but joined them as top eight finishers, and they end the initial phase at Girona.
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Aston Villa and Celtic are heading for the play-offs, and they face each other at Villa Park.