The Munster side has been named for Sunday’s Heineken Champions Cup clash against Wasps at the Coventry Building Society Arena.
Twelve players are set to make their senior Munster debuts with eight members of the Greencore Munster Rugby Academy included.
There are five debutants in the starting XV – Academy quartet Patrick Campbell, Scott Buckley, Eoin O’Connor and Daniel Okeke, and senior prop James French.
John Hodnett has recovered from a short-term ankle injury to make his first start in 13 months, and his Champions Cup debut, having missed the majority of last season with an achilles injury.
There are first starts of the season in red for Conor Murray, Damian de Allende and Chris Farrell with the latter making his 50th Munster appearance after returning from an abdomen injury.
Campbell starts at full-back with Andrew Conway and Keith Earls on either flank.
De Allende and Farrell team up in the centres with Murray and Joey Carbery in the half-backs.
Dave Kilcoyne packs down in the front row with Buckley and French.
Tadhg Beirne starts alongside O’Connor in the second row as captain Peter O’Mahony, Hodnett and Okeke complete the side.
Roman Salanoa is among the replacements having recovered from a knee injury with seven players in line to make their Munster debuts off the bench.
Summer addition Declan Moore and Academy quartet Mark Donnelly, Ethan Coughlan, Tony Butler and Jonathan Wren are all included.
Also named are Cork Constitution’s John Forde, a product of PBC and member of the Provincial Talent Squad, and Young Munster’s Conor Moloney, a member of the National Talent Squad.
Moloney came up through the ranks at Ennis RFC in the same team as Coughlan and Butler with the trio lining out for the Ennis RFC U18s as recently as last year.
Munster: Patrick Campbell; Andrew Conway, Chris Farrell, Damian de Allende, Keith Earls; Joey Carbery, Conor Murray; Dave Kilcoyne, Scott Buckley, James French; Eoin O’Connor, Tadhg Beirne; Peter O’Mahony (C), John Hodnett, Daniel Okeke.
Replacements: Declan Moore, Mark Donnelly, Roman Salanoa, John Forde, Conor Moloney, Ethan Coughlan, Tony Butler, Jonathan Wren.
Leinster play Bath at the Aviva Stadium tomorrow and the province has revealed three players are isolating after testing positive for Covid-19.
Head coach Leo Cullen has named a team including Irish players Hugo Keenan, James Lowe, Garry Ringrose, Jamison Gibson Park, Andrew Porter, Tadhg Furlong, Ronan Kelleher, Josh van der Flier and Caelan Doris.
Ross Byrne will play at out half and Rhys Ruddock will skipper the side in the absence of Johnny Sexton.
Ulster also play tomorrow, away to Clermont Auvergne in France.
South African World Cup winner Duane Vermeulen has been named in the back row for the province.
And Connacht host Stade Francais at the Sportsground on Sunday.
Jack Carty will captain the side with Shayne Bolton starting at outside centre.
There's also a new look second row of Oisin Dowling and Niall Murray.
