Arsenal will look close the gap to Premier League leaders Arsenal to six-points this afternoon.
The Gunners are unbeaten in three games against Manchester City ahead of hosting the reigning champions at half-four.
A win for Pep Guardiola's City would see them move to within three points of their second-place opponents.
Manchester United go for a fourth straight victory in all competitions when they host Crystal Palace.
While Spurs are on a run of fourth successive league defeats heading into their game at Brentford.
Mo Salah climbed up to sixth on the list of all-time Premier League goalscorers, with his brace helping Liverpool to a 2-nil win at in-form Bournemouth.
Nottingham Forest remain third after thrashing Brighton 7-nil - their biggest margin of victory this century.
Newcastle missed the chance to move into the top four as they suffered a 2-1 defeat to Fulham, with Aston Villa's hopes of Champions League qualification dented by a 2-nil loss at west Midlands rivals Wolves.
That result saw the Molineux side leapfrog Leicester, who drop back into the relegation zone after they were comfortably beaten 4-nil by Everton.
Bottom team Southampton ended a six match losing run to claim a second top flight win of the season, getting past fellow strugglers Ipswich 2-1.