The Munster side has been named for Saturday night’s big URC Interpro derby against Connacht at Thomond Park (7.35pm).
With a short six-day turnaround between last Sunday’s win over Scarlets and Saturday night’s clash, 14 changes have been made to the side.
Peter O’Mahony captains Munster on his 150th appearance for the province with last week’s Player of the Match Chris Cloete the only player retained from the Scarlets victory.
British & Irish Lion Tadhg Beirne starts in the second row on his first appearance of the campaign.
Mike Haley is named at full-back with Andrew Conway and Simon Zebo starting on either flank.
The half-backs are Craig Casey and Joey Carbery as Rory Scannell and Keith Earls form the centre partnership.
Dave Kilcoyne, Niall Scannell and John Ryan pack down in the front row with Jean Kleyn and Beirne in the engine room.
Captain O’Mahony, Cloete and Gavin Coombes start in the back row.
Recent Greencore Munster Rugby Academy graduate Jake Flannery is included among the replacements and set to make his first appearance of the season.
Fineen Wycherley and Jack O’Donoghue, who have started all three games so far this season, are also among the replacements.
Munster: Mike Haley; Andrew Conway, Keith Earls, Rory Scannell, Simon Zebo; Joey Carbery, Craig Casey; Dave Kilcoyne, Niall Scannell, John Ryan; Jean Kleyn, Tadhg Beirne; Peter O’Mahony (C), Chris Cloete, Gavin Coombes.
Replacements: Diarmuid Barron, Jeremy Loughman, Stephen Archer, Fineen Wycherley, Jack O’Donoghue, Neil Cronin, Jake Flannery, Dan Goggin.
Connacht centre Bundee Aki will make his first appearance since lining out for the Lions in tomorrow's United Rugby Championship game against Munster at Thomond Park.
Sammy Arnold, John Porch, Niall Murray and Conor Oliver also come into the side.
Irish Lions Tadhg Furlong, Ronan Kelleher and Jack Conan are back in the Leinster 15 for their encounter against the Scarlets at the RDS tomorrow.
Johnny Sexton skippers the team from out half.